Pediatric Emergency Airway Guide Section 1

Goals of Emergency Airway Therapy

A concise, clinically focused overview of indications, pediatric-specific considerations, safety, and noninvasive alternatives to tracheal intubation.

Purpose and goals of tracheal intubation

Tracheal intubation (TI) is a core resuscitative procedure for critically ill children. The primary goals are:

Indications for tracheal intubation

TI is indicated when there is actual or impending failure of:

It is also appropriate when:

Key point: In pediatric emergency care, neurologic failure and trauma are major drivers of TI, rather than primary respiratory failure alone.

Anatomic and physiologic considerations

Pediatric airway anatomy and physiology differ significantly from adults and directly influence intubation technique, equipment selection, and the risk of adverse events.

Anatomic features

  • Smaller airway diameter: Higher risk of obstruction and limited visualization.
  • Adenoidal hypertrophy: Common in young children; can impede nasal and oral access.
  • Developing teeth and tooth buds: Susceptible to injury during laryngoscopy.
  • Primary teeth: Easily avulsed or aspirated with poorly controlled instrumentation.
  • Large tongue: Tongue is large relative to the oropharynx, obstructing the view.
  • Superior larynx: Larynx lies higher (C3–C4 in infants vs. C4–C5 in adults), making angles more acute.
  • Weaker hyoepiglottic ligament: Lifting the epiglottis via the vallecula is less efficient than in adults.
  • Long, floppy epiglottis: Narrow and acutely angled, more likely to obscure the glottic opening.
  • Narrowest point: Historically described at the cricoid cartilage, but current evidence supports the glottis (vocal cords) as the functionally narrowest region, supporting the routine use of cuffed endotracheal tubes in all ages.

Physiologic features

  • Smaller lungs and fewer alveoli: Reduced oxygen reservoir and gas exchange surface area.
  • High chest wall compliance: Cartilaginous chest wall with poor recoil increases work of breathing.
  • Closing volume > FRC: Terminal bronchioles may close above functional residual capacity, predisposing to atelectasis and collapse.
  • Higher metabolic rate: Increased oxygen consumption, especially in infants, leading to rapid desaturation during apnea.
  • High vagal tone: Greater tendency for bradycardia with hypoxia, suctioning, or laryngoscopy.
Bottom line: Children desaturate quickly and are more prone to physiologic collapse during TI. Meticulous preoxygenation and minimizing apnea time are critical.

Provider exposure, safety profile, and training

Low frequency and skill maintenance

Pediatric TI is relatively infrequent, even in high-volume pediatric emergency departments. Many clinicians perform only a small number of intubations per year, and some perform none, leading to potential skill decay and variability in performance.

Trainee exposure has declined, and observational studies show modest success rates for residents and fellows on their first attempts. These patterns highlight the importance of structured training and careful selection of the initial intubator when a child requires TI.

Adverse events and physiologic instability

Recent video-based and registry data suggest that serious physiologic changes during pediatric TI are more common than previously appreciated:

High-risk profile: TI in children is a low-frequency, high-stakes procedure with meaningful risk of hypoxemia and hemodynamic compromise, especially with prolonged or multiple attempts.

Approaches to improving safety

To mitigate risk and maintain competence, departments can:


Low-frequency procedure High-stakes Simulation & QA Risk of hypoxia & bradycardia

Alternatives to endotracheal intubation

Before proceeding to TI, consider whether noninvasive support can stabilize the child, particularly in:

High-flow nasal cannula (HFNC)

HFNC delivers heated, humidified oxygen at high flows that can meet or exceed the patient’s inspiratory demands.

  • FiO₂: 21–100%, with adjustable fraction of inspired oxygen.
  • Age-based flow rates: Smaller children often receive weight-based flows; older children and adults may receive fixed flows (e.g., up to 60 L/min in adults).
  • Mechanisms: Reduced room air entrainment, nasopharyngeal dead space washout, and low-level positive airway pressure.
  • Comfort: Typically better tolerated than masks; allows speaking and feeding in appropriate patients.
  • Safety: Excellent overall safety profile; barotrauma is rare and mostly limited to case reports.
Clinical use: HFNC is commonly used as first-line support in conditions such as bronchiolitis, pneumonia, and some asthma exacerbations when work of breathing is increased but immediate intubation is not yet required.
Noninvasive Support

High-Flow Nasal Cannula (HFNC)

HFNC provides heated, humidified oxygen at high flows that meet or exceed the patient’s inspiratory demand. It improves oxygenation, reduces work of breathing, and is well tolerated across pediatric age groups.

Suggested HFNC Flow Rates

Clinical note: Cannula size should occupy < 50% of the nares to avoid inadvertent CPAP.
Patient Weight (kg) Starting Flow (L/min) Maximum Flow (L/min)
< 5 6 8
5–10 8 15
10–20 15–20 20
20–40 25–30 40
> 40 25–30 40–60

Clinical Pearls

Noninvasive Support

Noninvasive Ventilation (NIV)

NIV provides mechanical respiratory support without endotracheal intubation. It includes CPAP (continuous positive airway pressure) and BPAP (bilevel positive airway pressure). Both can be delivered through nasal masks, full-face masks, or helmet interfaces.

CPAP

Best for:

  • Hypoxemic respiratory failure
  • Upper airway obstruction (e.g., croup, post-extubation stridor)

Typical settings:

  • 5–10 cm H₂O continuous pressure

BPAP

Best for:

  • Hypercarbic respiratory failure
  • Severe hypoxemia requiring higher mean airway pressures
  • Neuromuscular weakness or fatigue

Typical settings:

  • IPAP: 8–22 cm H₂O
  • EPAP: 5–10 cm H₂O
  • Optional backup rate for apnea/hypopnea
Interface selection is critical: choose the most comfortable option with minimal leak.

Advantages of NIV

Contraindications

Complications

Clinical pearl: Most children tolerate NIV with coaching and patience; mild anxiolysis may help.
Advanced Airway

Approach to Endotracheal Intubation

Rapid sequence intubation (RSI) is the preferred method for securing the airway in critically ill children. RSI improves intubating conditions and increases first-attempt success compared with sedation-only approaches. It involves the near-simultaneous administration of a sedative and a neuromuscular-blocking agent (NMBA) to produce unconsciousness, immobility, and suppression of airway reflexes.

RSI vs Modified RSI vs Sedation-Only

Clinical pearl: Children desaturate quickly—modified RSI with controlled ventilation is often safer than strict “no BMV” RSI.

The 7 Ps of RSI

Preparation

Equipment

Anticipating the need for escalating airway support and ensuring all equipment is ready is essential for safe pediatric intubation. Oxygen sources, passive oxygenation devices, and a functioning bag-valve-mask (BVM) must be immediately available.

Required Equipment

SOAP ME Checklist

Many centers now use pre-intubation checklists to ensure readiness of equipment, personnel, and medications.
Airway Equipment

Endotracheal Tubes (ETTs)

Both cuffed and uncuffed ETTs are used in pediatrics. Modern evidence supports the safety of cuffed tubes beyond the newborn period, and they are now widely recommended.

Cuffed vs Uncuffed Tubes

PALS and anesthesia guidelines: Cuffed ETTs are safe and preferred in most children beyond the newborn period.

When Cuffed Tubes Are Favored

Cuff Pressure

ETT Sizing

ETT sizes are based on internal diameter (mm). Methods include:

Age-Based Formulas

Always have one tube size smaller and one size larger available.

Stylets

Airway Equipment

Direct Laryngoscopes

Direct laryngoscopy (DL) uses a handle and blade to create a direct line of sight to the glottis. Blade choice depends on patient age, anatomy, and clinician preference.

Curved vs Straight Blades

Blade Size Selection

Tip: Choose a blade approximately equal to the distance from the upper incisors to the angle of the mandible when age is uncertain.
Advanced Airway

Video Laryngoscopes (VL)

Video laryngoscopy (VL) uses a camera at the distal end of the blade to visualize the glottis without requiring a direct line of sight. Unlike direct laryngoscopy (DL), which depends on aligning the oral, pharyngeal, and tracheal axes, VL allows operators to view the airway on a monitor while navigating around the natural curvature of the upper airway.

Why VL Improves Visualization

Most helpful for: novice clinicians and patients with difficult airways (e.g., cervical spine immobilization, macroglossia, micrognathia).

Evidence Summary

VL Devices

Common Pediatric Videolaryngoscopes

Several VL devices are available for pediatric use, differing in blade geometry, cost, reusability, and technique. Only a few systems offer blades sized for the full pediatric age range from neonates through adolescents.

Key Devices

Device Eligible Ages Unique Features Tips for Use
Airtraq Neonate–Adult Optical system; optional video camera; disposable single-use; channeled blade; color-coded to Broselow. Begin looking through viewfinder early; if ETT catches below posterior cartilages, lift device upward rather than rocking back.
Storz C-MAC Neonate–Large Adult Miller and Macintosh blades; can be used for DL or VL; disposable blades available; hyperangulated “D” blades in pediatric sizes. Avoid placing blade too close to glottis—improves view but worsens tube delivery; supervisor can guide using screen view.
GlideScope Neonate–Large Adult Hyperangulated blade (60°); reusable and disposable options; full pediatric size range; excellent for anterior airways. Use rigid stylet; insert shallowly for broader view; partially withdraw stylet after passing cords; look into mouth during insertion to avoid trauma.
King Vision Neonate–Large Adult Disposable blades; size 1 unchanneled for infants; size 2–3 channeled or unchanneled; lower cost than C-MAC/GlideScope. With channeled blades, lift device upward (not backward) if ETT catches below posterior cartilages.
Truview EVO2 Neonate–Large Adult Optical system; optional video monitor; continuous oxygen delivery; refracted view enlarges field. Oxygen insufflation delays desaturation; midline insertion; may require gentle lifting of tongue and soft tissue.
McGrath Series 5 School Age–Adult Portable, self-contained; disposable blades; adjustable blade length. Midline approach; tip sits in vallecula; bougie or ELM may assist with tube delivery.
Pentax-AWS Adolescents–Adults Channeled blade; single-use; crosshair targeting; optional oxygen or suction channel. Pass blade under epiglottis; preloading ETT with bougie or using ELM may improve success.
Clinical pearl: VL is increasingly used as a first-line device in pediatric emergency airways, especially for trainees and anticipated difficult airways.
RSI Preparation

Preoxygenation

Because children desaturate rapidly during apnea, maximizing preoxygenation is essential before intubation. Traditional preoxygenation in the ED uses a nonrebreather mask (NRB), often supplemented with nasal cannula oxygen. While “flush rate” oxygen (>15 L/min) improves NRB performance in adults, its benefit in small children with lower minute ventilation is less clear.

Methods of Preoxygenation

Suggested Nasal Cannula Flow Rates for Apneic Oxygenation

Clinical pearl: Higher flows have been safely used in fasted OR patients; risk of harm is low when cannula size does not occlude the nares.
RSI Preparation

Patient Positioning

Intubation and BVM ventilation are traditionally performed with the patient supine. However, positioning can significantly influence airway patency, visualization, and ventilation.

Key Positioning Strategies

Clinical pearl: Head-elevated positioning may reduce airway obstruction and improve first-pass success—an evolving best practice in pediatrics.
RSI Medications

Sedatives

RSI sedatives should produce rapid unconsciousness with minimal hemodynamic or intracranial pressure effects. No agent is ideal for all situations; selection depends on the child’s physiology and clinical context.

Common RSI Sedatives

Medication Dose
Benzodiazepines (midazolam, lorazepam) 0.2–0.3 mg/kg
Fentanyl 1–2 mcg/kg
Ketamine 1–3 mg/kg
Etomidate 0.3 mg/kg
Propofol 1–4 mg/kg

Ketamine

Etomidate

Propofol

Benzodiazepines

Critical reminder: Any sedative can precipitate cardiovascular collapse in unstable children. In profound shock, very low-dose or no sedative may be appropriate if the child is already unconscious.

Agents such as dexmedetomidine, remifentanil, and propofol/remifentanil combinations are being studied but have limited evidence in pediatric ED RSI.

RSI Medications

Neuromuscular-Blocking Agents (Paralytics)

Paralytics eliminate laryngeal reflexes and muscle tone, improving intubating conditions. Ideal agents have rapid onset and short duration, though duration must be balanced with the need for ongoing paralysis during repeated attempts.

Medication Dose
Succinylcholine 1–2 mg/kg
Rocuronium 0.6–1.2 mg/kg
Vecuronium 0.1–0.2 mg/kg
Cisatracurium 0.1–0.2 mg/kg

Succinylcholine

Rocuronium

Other Nondepolarizing Agents

Critical reminder: After intubation, ensure ongoing sedation—paralyzed patients cannot signal distress.
RSI Adjuncts

Adjunctive Agents

Atropine

Atropine reduces the risk of bradycardia associated with laryngoscopy or succinylcholine use—a phenomenon more common in infants and young children. It also decreases oral secretions, which may be helpful when ketamine is used, although its antisialogogue effect requires 15–20 minutes to take effect and therefore has limited impact during emergent RSI.

Lidocaine

Lidocaine has historically been used to blunt the autonomic response to laryngoscopy and reduce intracranial pressure (ICP), particularly in traumatic brain injury. However, adult meta-analyses show no clear benefit, and pediatric data are lacking. Routine use of lidocaine as an RSI adjunct is not recommended.

Post‑Intubation

Postprocedure Management

Immediately after intubation, correct placement of the endotracheal tube (ETT) must be confirmed. Esophageal intubation remains a significant risk, especially in children and prehospital settings.

Primary Confirmation: End‑Tidal CO₂

Secondary Confirmation

Even when the tube is visualized passing through the cords, secondary confirmation is required due to the risk of misidentification, poor visualization, or tube dislodgement.

Clinical caution: Auscultation is often unreliable in noisy resuscitations and may falsely reassure providers during esophageal intubation.

Pulse Oximetry

Continuous pulse oximetry is essential but should not be relied upon for early detection of esophageal intubation. Children may desaturate rapidly, but in some cases there is a lag before hypoxia develops.

Imaging

Post‑Intubation

Maintenance of Sedation

After intubation, sedation must be promptly re‑established. Paralytics such as rocuronium often outlast the induction sedative, leaving the patient paralyzed but awake unless additional sedation is administered.

Critical reminder: Paralyzed patients cannot signal distress—sedation must be proactively maintained.
Rescue Airway

Rescue Devices in Pediatric Airway Management

When to Use Rescue Devices

Rescue devices are used in “can’t intubate, can’t ventilate” situations when face‑mask ventilation is ineffective. They are not definitive airways and do not protect against aspiration, but they can prevent life‑threatening desaturation while additional help or equipment is mobilized.

Supraglottic Airways (SGAs)

Laryngeal mask airways (LMAs) are the most commonly used SGAs in both adults and children. They consist of a teardrop‑shaped cuff that sits in the hypopharynx above the glottis, directing airflow into the trachea.

Key Features

Evidence: SGAs have demonstrated comparable or improved outcomes to prehospital intubation in adult cardiac arrest and neonatal resuscitation.

Other Supraglottic Devices

Esophageal Combination Tube (Combitube)

Laryngeal Tube

Perilaryngeal Airway