| Generic
Name |
Brand
Name |
Site
of release |
Notes |
Dosage |
| Sulfasalazine* |
Azulfidine Salazopyrin Pyralin |
Colon |
5-ASA Supplement w/ Folic Acid |
30-100mg/kg/day (max 4g) active
colitis 25-80mg/kg/day (max 4g) for maint (gradually increase dose over 1-2wks) monitor for allergic reaction |
| Olsalazine |
Dipentum |
Colon |
5-ASA Not approved for <18y |
Clinical trial - inferior to
sulfasalazine (1) |
| Balsalazide |
Colazide Colazal |
Colon |
5-ASA |
60-100mg/kg/day (max 4g) active
colitis 30-100mg/kg/day (max 4g) for maint |
| Mesalamine (Mesalazine) |
Lialda |
TI Colon |
5-ASA
derivative Enteric Coating (dissolves at pH>7) |
60-100mg/kg/day
(max 4g) active colitis 30-100mg/kg/day (max 4g) for maint |
| Mesalamine (Mesalazine) |
Asacol |
TI Colon |
5-ASA
derivative Eudragit-S coating |
60-100mg/kg/day
(max 4g) active colitis 30-100mg/kg/day (max 4g) for maint |
| Mesalamine (Mesalazine) |
Apriso |
TI Colon |
5-ASA
derivative |
60-100mg/kg/day
(max 4g) active colitis 30-100mg/kg/day (max 4g) for maint |
| Mesalamine |
Pentasa |
Duodenum to Colon |
5-ASA derivative -microspheres w/i an ethylcellulose semi - permeable membrane |
60-100mg/kg/day (max 4g) active
colitis 30-100mg/kg/day (max 4g) for maint |
| Mesalamine |
Canasa
supp |
Rectum (Suppository) |
5-ASA
derivative |
500 -
1000mg PR daily (Consider BID dosing) |
| Mesalamine |
Rowasa |
Rectum,
Sigmoid colon (Enema) |
5-ASA
derivative |
4000mg/60mL
PR daily |
| ----------- |
------------ |
--------------- |
-------------------- |
----------------------- |
| Hydrocortisone |
*Multiple* Cortifoam |
Rectum (Rectal foam/ Enema) |
Corticosteroid |
100mg PR daily to BID |
| Budesonide |
Entocort (PO) |
TI Colon |
Corticosteroid Age > 6y Can open capsule, If target is small bowel |
9mg x 8wks followed by 6mg x
4wks maint Age 10-19: 12mg x4wks then 9mg x 3wks then 6mg x 3wks (References: 2,3,4) |
| Budesonide |
Uceris |
Colon |
Corticosteroid Age > 6y |
9mg x 8wks followed by 6mg x 4wks (Discontinue at 12wks total) |
| Prednisone |
Prednisone |
Systemic |
Costicosteroid |
1-2mg/kg/day div q12 PO/IV After 2wks, Taper over 4-8wks Max 60mg/day |
| ----------- |
---------- |
------------ |
-------------------- |
------------------------- |
| Methotrexate |
Systemic combination Rx with Biologic |
Immunomodulator, Antineoplastic, antirheumatic Supplement w/ Folic Acid 1mg po qd |
<30kg: 10mg once weekly 30-39kg: 15mg once weekly 40-49kg: 20mg once weekly >50kg: 25mg once weekly |
|
| Azathioprine** |
Imuran |
Systemic |
Immunomodulator Obtain TPMT level prior to dosing |
Int TPMT: 1-1.5mg/kg/day Normal/hi TPMT: 2-3mg/kg/day |
| 6-Mercaptopurine |
6-MP |
Systemic |
Immunomudulator ***Risk of: T-cell lymphoma Hepatosplenic T-cell lymphoma Lymphoproliferative disorders Other Malignancies |
Int TPMT: 0.5-0.75 mg/kg/day Normal/hi TPMT: 1-1.5mg/kg/day |