IBD Panel
The antibodies included in the panel:
- ASCA (anti-Saccharomyces cerevisiae antibodies),
- ALCA (antilaminaribioside carbohydrate antibodies),
- ACCA (antichitobioside carbohydrate antibodies),
- AMCA (antimannobioside carbohydrate antibodies).
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Results:
When the only positive marker is pANCA, the interpretive
comment on the report will read: "Suggestive of ulcerative
colitis."
When only one of ACCA, ALCA, AMCA, or gASCA is positive and pANCA
is negative, the interpretive comment will read: "Suggestive
of Crohn's disease. Pattern is not conclusive for disease
behavior risk stratification."
When only one of ACCA, ALCA, AMCA, or gASCA is positive and pANCA is
positive, the interpretive comment will read: "Suggestive of
inflammatory bowel disease. Pattern is not conclusive for any
specific disease form."
When any two of ACCA, ALCA, AMCA, or gASCA are positive and
pANCA is positive or negative, the interpretive comment will read:
"Suggestive of Crohn's disease with high risk of aggressive
disease behavior (development of strictures or fistulae)."
When any three or more of ACCA, ALCA, AMCA, or gASCA are positive
and pANCA is positive or negative, the interpretive comment will
read: "Suggestive of Crohn's disease with the very high risk of
aggressive disease behavior (development of strictures or
fistulae)."
When all markers are negative, the interpretive comment on
the report will read: "Pattern is not suggestive of inflammatory
bowel disease."
References:
https://www.labcorp.com/tests/162045/inflammatory-bowel-disease-ibd-expanded-profile