5th Disease (erythema infectiousum or slapped cheek disease)
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Sx: 
-Mild fever with Rash
-school age child
-starts with nonspecific (fever, coryza, headache, nausea, diarrhea) [viremia]
-2 to 5 days later classic erythematous malar rash with CIRCUMORAL PALLOR followed by reticulated lacelike rash on trunk and extremities

-incubation period 1-3 weeks, 

--symtoms can resolve before rash appears (i.e. patient feels well but now has rash)

***A typical feature of 5th is recrudescence of the rash after a variety of nonspecific stimuli, such as change in temperature, exposure to sunlight, exercise, or emotional stress.


Tx: supportive


Other clinical manifestations of Parvovirus B19:
-5th Disease
-Arthropathy
-Transient aplastic crisis (w/ chronic hemolytic disorers)
-Fetal infection leading to non-immune hydrops fetalis, intrauterine fetal death, or miscarriage
-Pure red blood cell aplasia in immunocompromised individuals

Prevention:

 Studies of rhinoviruses and enteroviruses, which are also spread by person-to-person contact, fomites, and large droplet aerosol, and are stable in the environment, suggest that hand washing and not sharing food or drinks is likely to prevent, at least partially, spread of B19 in a variety of settings.