Tretinoin - USE AT NIGHT, a pea-sized amount of medication is usually sufficient to cover the face. Skin should be dry at the time of application Benzoyl Peroxide - Use in Morning. Do not use at the same time as Tretinoin! May bleach clothing. Wash face and gently pat dry prior to application. Apply thin layer to cover face or areas where pimples occur. When using these medications: Avoid using over-the-counter irritating products, such as harsh soaps, toners, astringents, and alpha hydroxy acid or salicylic acid products. Use a gentle skin cleanser (Dove, Ceta-klenz)